Structural basis for SRY-dependent 46-X,Y sex reversal: Modulation of DNA bending by the naturally occuring M9I mutation Overall comparison of wild type SRY (red) and M9I SRY-DNA complexes Comparison of DNA in wild type (red with green DNA axis) and M9I (blue with yellow DNA axis) SRY-DNA complex Comparison of surfaces of wild type (a and b) and M9I (c and d) SRY-DNA complexes Detailed views of contacts involving M9 in wild type and I9 in M9I mutant SRY-DNA complexes Werner, M.H., Huth, J.R., Gronenborn, A.M. & Clore, G.M. (1995) Molecular basis of human 46X,Y sex reversal revealed from the three-dimensional solution structure of the human SRY-DNA complex. Cell 81, 705-714. pubmed
Murphy, E.C., Zhurkin, V.B., Louis, J.M., Cornilescu, G. and Clore, G.M. (2001) Structural basis for SRY-dependent 46-X,Y sex reversal: modulation of DNA bending by a naturally occuring point mutation. J. Mol. Biol. 312, 481-499. pubmed PDF
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Disclaimer: Dr. Clore created this website in his personal capacity. The information on this site and views expressed are his own and do not necessarily represent the views of the National Institutes of Health or the United States Government
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