Solution structure of the complete 44 kDa ectodomain of SIV gp41 and design of a chimeric protein, NCCG-gp41 that inhibits HIV-Env mediated fusion

 

Diagram of HIV-env mediated cell fusion and solution structure of the complete 44 kDa ectodomain of SIV gp41

gp41

 

Design of the HIV-Env mediated fusion inhibitor NCCG-gp41

gp41 inhibitor design

 

Inhibition of HIV-Env mediated cell fusion by NCCG-gp41, and the C34 and N36 peptides

inhibition of hiv fusion

 

Caffrey, M., Cai, M., Kaufman, J., Stahl, S.J., Wingfield, P.T., Covell, D.G., Gronenborn, A.M. & Clore, G.M. (1998) Three-dimensional solution structure of the 44 kDa ectodomain of SIV gp41. EMBO J. 17, 4572-4584. pubmed PDF

Louis, J.M., Bewley, C.A. & Clore, G.M. (2001) Design and properties of NCCG-gp41, a chimeric gp41 molecule with nanomolar HIV-fusion inhibitory activity. J. Biol. Chem. 276, 29485-29489. pubmed PDF

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Disclaimer: Dr. Clore created this website in his personal capacity. The information on this site and views expressed are his own and do not necessarily represent the views of the National Institutes of Health or the United States Government